__ Ages Here you will find an overview of the requirements, a checklist for applicants and reviewers, detailed instructions, and responsibilities of applicants, reviewers, and NIH staff. Justifications. Additional (e.g., non-pharmaceutical) means to avoid discomfort, distress, pain, or injury, including palliative care. Home. Indicate why the research goals cannot be accomplished using an alternative model (e.g., computational, human, invertebrate, in vitro). Provide a justification for methods of euthanasia that are not consistent with the American Veterinary Medical Association (AVMA) Guidelines for the Euthanasia of Animals. If live vertebrate animals are to be used, applicants must address the following criteria: 1. Minimization of Pain and Distress (Vertebrate Animals Section) Calling all NIH applicants proposing research with vertebrate animals – check out the latest online learning module on the Vertebrate Animals Section in grant applications.This interactive module will assist applicants in preparing this section of the application, and will serve as a valuable resource for reviewers in evaluating the Vertebrate Animal Section of applications and proposals. __ Identify (by name or class) any tranquilizers, analgesics, anesthetics, and other treatments (e.g., antibiotics) and describe their use. 2020 Mar 9. doi: 10.1007/s12551-020-00654-z. Epub 2020 Feb 4. Explain why the research goals cannot be accomplished using an alternative model (e.g., computational, human, invertebrate, in vitro). Provides reviewers with instructions for reviewing the VAS (e.g., worksheet), noting that all criteria must be evaluated as appropriate for the VAS to be ACCEPTABLE. U.S. Government Principles require grantees to consider mathematical models, computer simulation, and in vitro biological systems. Writing a K99 grant involves series of steps and requires significant amount of work, both from writing the Science and Administrative sections. __ Why research goals cannot be accomplished using an alternative model (e.g., computational, human, invertebrate, in vitro), 3. Vertebrate Animals Section in grant applications. NOT-OD-16-006 announced and described the changes implemented to simplify and remove redundancies in the Vertebrate Animals Section (VAS) for NIH grant, cooperative agreement, and contract applications. responsibilities of applicants, reviewers, and NIH staff. NIH application packages due on or after May 25, 2020, will use the FORMS-F application package. Provide a concise description of the proposed procedures to be used that involve vertebrate animals in the work outlined in the application or proposal. The following guidance is provided to assist applicants and offerors in preparing the Vertebrate Animals Section (VAS) for submission to the NIH, and to assist reviewers in evaluating the VAS of applications and proposals. Considering alternatives to animals in your application is the topic of our next NIH All About Grants podcast.Drs. For example, the use of non-human primates, dogs, or cats should be thoroughly justified. Describe the animals and their proposed use. Minimization of Pain and Distress (Vertebrate Animals Section). Follow the instructions for Vertebrate Animals in the SF 424 Form Instructions. 1. Justifications (Vertebrate Animals Section). Provide a concise description of the proposed procedures to be used that involve live vertebrate animals in the work outlined in the Research Strategy section. Identify the species, strains, ages, sex, and total number of animals by species to be used. Method of Euthanasia (Cover Page Supplement / PHS Fellowship Supplemental Form). Confirms whether the offeror has an Animal Welfare Assurance and IACUC approval. OLAW also offers a 30-minute training module on how to Complete the Vertebrate Animals Section (VAS). Works with the applicant to provide information to the Office of Laboratory Animal Welfare (OLAW) allowing resolution of the animal welfare concerns. 3. Provide a concise description of the proposed procedures to be used that involve live vertebrate animals. Date: June 15, 2018 Last Revision: October 8, 2020. Offeror has an animal Welfare concerns, pain, and humane endpoints and Euthanasia ( e.g., )!: Date: June 15, 2018 Last Revision: October 8, 2020 VAS for applications proposing use. Name or class of pharmacological agents, if necessary an animal Welfare ( OLAW website! Involves series of steps and requires significant amount of work, both from writing the Science and Administrative.! Be used that involve live Vertebrate animals Section ( VAS ) Typically, all of the Welfare. 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